OR19-6 A Novel Anti-CD40 Monoclonal Antibody, Iscalimab, Successfully Treats Graves’ Hyperthyroidism

Objective: Graves’ disease (GD) is an autoimmune disorder characterized by thyrotropin receptor autoantibody (TSHR-Ab)-mediated pathology, leading to hyperthyroidism. To date there is no pharmacotherapy that addresses the underlying pathogenesis. The CD40-CD154 (CD40L) co-stimulatory pathway plays a...

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Detalles Bibliográficos
Publicado en:J Endocr Soc
Autores principales: Kahaly, George, Stan, Marius, Gergely, Peter, Colin, Laurence, Amer, Ahmed, Schuhmann, Imelda, Espie, Pascal, Rush, James, Basson, Craig, He, YanLing
Formato: Artigo
Lenguaje:Inglês
Publicado: Endocrine Society 2019
Materias:
Thyroid
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554936/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-OR19-6
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