OR30-4 Parathyroid Hormone-related Peptide Antagonist and Inverse Agonist Reduce Breast Cancer Metastasis to Bone and Bone Loss

Bone is the most frequent site for breast cancer metastasis. Metastatic cancer cells secrete parathyroid-hormone related peptide (PTHrP) that stimulates bone turnover, releasing growth factors and creating a cavity for tumor growth. Current treatments include bisphosphonates and the RANK Ligand inhi...

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Detalhes bibliográficos
Publicado no:J Endocr Soc
Main Authors: Ponnapakkam, Tulasi, Anbalagan, Murali, Saeg, Fouad, Emneser, Waleed, Kang, Yibin, Gensure, Robert, Rowan, Brian
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2019
Assuntos:
Bone and Mineral Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554809/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-OR30-4
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