Inhibition of the FAD containing ER oxidoreductin 1 (Ero1) protein by EN-460 a strategy for treatment of multiple myeloma

Multiple myeloma (MM) cells demonstrate high basal endoplasmic reticulum (ER) stress and are typically exquisitely sensitive to agents such as proteasome inhibitors that activate the unfolded protein response. The flavin adenosine dinucleotide (FAD) containing endoplasmic reticulum oxidoreductin enz...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Hayes, Karen, Batsomboon, Paratchata, Chen, Wei-Chih, Johnson, Brennan D., Becker, Andreas, Eschrich, Steven A., Yang, Yan, Robart, Aaron R., Dudley, Gregory, Geldenhuys, Werner J., Hazlehurst, Lori A
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554731/
https://ncbi.nlm.nih.gov/pubmed/30850265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2019.02.016
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