Adoptive Transfer of NKG2D CAR mRNA-Engineered Natural Killer Cells in Colorectal Cancer Patients

By fusing the extracellular domain of the natural killer (NK) cell receptor NKG2D to DAP12, we constructed a chimeric antigen receptor (CAR) to improve NK cell tumor responses. An RNA electroporation approach that provides transient expression of the CAR was adopted as a risk mitigation strategy. Ex...

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Detalhes bibliográficos
Publicado no:Mol Ther
Principais autores: Xiao, Lin, Cen, Dongzhi, Gan, Haining, Sun, Yan, Huang, Nanqi, Xiong, Hanzhen, Jin, Qiongmei, Su, Liqun, Liu, Xuejuan, Wang, Kejian, Yan, Guangrong, Dong, Tianfa, Wu, Shangbiao, Zhou, Pengzhi, Zhang, Jinshan, Liang, Weixiang, Ren, Junlan, Teng, Yaoshu, Chen, Can, Xu, Xue Hu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554529/
https://ncbi.nlm.nih.gov/pubmed/30962163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.03.011
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