Biology and Bias in Cell Type-Specific RNAseq of Nucleus Accumbens Medium Spiny Neurons

Subcellular RNAseq promises to dissect transcriptional dynamics but is not well characterized. Furthermore, FACS may introduce bias but has not been benchmarked genome-wide. Finally, D1 and D2 dopamine receptor-expressing medium spiny neurons (MSNs) of the nucleus accumbens (NAc) are fundamental to...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Kronman, Hope, Richter, Felix, Labonté, Benoit, Chandra, Ramesh, Zhao, Shan, Hoffman, Gabriel, Lobo, Mary Kay, Schadt, Eric E., Nestler, Eric J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554355/
https://ncbi.nlm.nih.gov/pubmed/31171808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44798-9
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