Quantitative Proteomics Links the Intermediate Filament Nestin to Resistance to Targeted BRAF Inhibition in Melanoma Cells

Targeted inhibition of mutated kinases using selective MAP kinase inhibitors in malignant melanoma often results in temporary improvement of clinical symptoms followed by rapid development of resistance. To gain insights in molecular processes that govern resistance, we performed SILAC-based quantit...

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Bibliografiske detaljer
Udgivet i:Mol Cell Proteomics
Main Authors: Schmitt, Marisa, Sinnberg, Tobias, Nalpas, Nicolas C., Maass, Annika, Schittek, Birgit, Macek, Boris
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6553926/
https://ncbi.nlm.nih.gov/pubmed/30890564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA119.001302
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