Microdialysis combined with liquid chromatography-tandem mass spectrometry for the quantitation of gemifloxacin and its application to a muscle penetration study in healthy and MRSA-infected rats

Pharmacological efficacy is based on the drug concentration in target tissues, which usually cannot be represented by the plasma concentration. The purpose of this study was to compare the pharmacokinetic characteristics of gemifloxacin in plasma and skeletal muscle and evaluate its tissue penetrati...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhao, Rui, Wang, Qing, Hu, Xin-Xin, Nie, Tong-Ying, Yang, Xin-Yi, Li, Cong-Ran, Lu, Xi, Wang, Xiukun, Jiang, Jian-Dong, Pang, Jing, You, Xue-Fu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6553852/
https://ncbi.nlm.nih.gov/pubmed/31170198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217573
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