Vitamin A Metabolism by Dendritic Cells Triggers an Antimicrobial Response against Mycobacterium tuberculosis

Epidemiological evidence correlates low serum vitamin A (retinol) levels with increased susceptibility to active tuberculosis (TB); however, retinol is biologically inactive and must be converted into its bioactive form, all-trans retinoic acid (ATRA). Given that ATRA triggers a Niemann-Pick type C2...

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Publicado en:mSphere
Main Authors: Kim, Elliot W., De Leon, Avelino, Jiang, Zhichun, Radu, Roxana A., Martineau, Adrian R., Chan, Edward D., Bai, Xiyuan, Su, Wen-Lin, Montoya, Dennis J., Modlin, Robert L., Liu, Philip T.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2019
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6553556/
https://ncbi.nlm.nih.gov/pubmed/31167948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00327-19
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