Mutation of the ATPase Domain of MutS Homolog-5 (MSH5) Reveals a Requirement for a Functional MutSγ Complex for All Crossovers in Mammalian Meiosis

During meiosis, induction of DNA double strand breaks (DSB) leads to recombination between homologous chromosomes, resulting in crossovers (CO) and non-crossovers (NCO). In the mouse, only 10% of DSBs resolve as COs, mostly through a class I pathway dependent on MutSγ (MSH4/ MSH5) and MutLγ (MLH1/ML...

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Detalhes bibliográficos
Publicado no:G3 (Bethesda)
Main Authors: Milano, Carolyn R., Holloway, J. Kim, Zhang, Yongwei, Jin, Bo, Smith, Cameron, Bergman, Aviv, Edelmann, Winfried, Cohen, Paula E.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2019
Assuntos:
Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6553527/
https://ncbi.nlm.nih.gov/pubmed/30944090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.119.400074
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