SUN-215 Phosphorylation Site of Gonadotropin Regulated Testicular RNA Helicase (GRTH/DDX25) and GRTH/PKA Binding Interface: Biochemical and Structural Studies

Gonadotropin Regulated Testicular Helicase (GRTH/DDX25), expressed in the male gonad, is essential for the completion of spermatogenesis. Our early studies revealed a missense mutation (R242H) of GRTH in 5.8 % of a patient population with azoospermia. Transfection of the mutant protein in COS-1 cell...

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Bibliographic Details
Published in:J Endocr Soc
Main Authors: Raju, Murugananth Kumar, Hassan, Sergio, Kavarthapu, Raghuveer, Anbazhagan, Rajakumar, Dufau, Maria
Format: Artigo
Language:Inglês
Published: Endocrine Society 2019
Subjects:
Reproductive Endocrinology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6553102/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-SUN-215
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