Stella protein facilitates DNA demethylation by disrupting the chromatin association of the RING finger–type E3 ubiquitin ligase UHRF1

Stella is a maternal gene required for oogenesis and early embryogenesis. Stella overexpression in somatic cells causes global demethylation. As we have recently shown, Stella sequesters nuclear ubiquitin-like with PHD and RING finger domains 1 (UHRF1), a RING finger–type E3 ubiquitin ligase essenti...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Du, Wenlong, Dong, Qiang, Zhang, Zhuqiang, Liu, Baodong, Zhou, Ting, Xu, Rui-ming, Wang, Hailin, Zhu, Bing, Li, Yingfeng
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2019
Ämnen:
DNA and Chromosomes
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6552428/
https://ncbi.nlm.nih.gov/pubmed/31018966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008008
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk