Protein O-GlcNAcylation Is Essential for the Maintenance of Renal Energy Homeostasis and Function via Lipolysis during Fasting and Diabetes

BACKGROUND: Energy metabolism in proximal tubular epithelial cells (PTECs) is unique, because ATP production largely depends on lipolysis in both the fed and fasting states. Furthermore, disruption of renal lipolysis is involved in the pathogenesis of diabetic tubulopathy. Emerging evidence suggests...

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Detalles Bibliográficos
Publicado en:J Am Soc Nephrol
Autores principales: Sugahara, Sho, Kume, Shinji, Chin-Kanasaki, Masami, Tomita, Issei, Yasuda-Yamahara, Mako, Yamahara, Kosuke, Takeda, Naoko, Osawa, Norihisa, Yanagita, Motoko, Araki, Shin-ichi, Maegawa, Hiroshi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Nephrology 2019
Materias:
Basic Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551777/
https://ncbi.nlm.nih.gov/pubmed/31043434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018090950
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