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Formyl-methionine as an N-degron of a eukaryotic N-end rule pathway
In bacteria, nascent proteins bear the pretranslationally generated N-terminal (Nt) formyl-methionine (fMet) residue. Nt-fMet of bacterial proteins is a degradation signal, termed fMet/N-degron. By contrast, proteins synthesized by cytosolic ribosomes of eukaryotes were presumed to bear unformylated...
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| Udgivet i: | Science |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6551516/ https://ncbi.nlm.nih.gov/pubmed/30409808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aat0174 |
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