Tellurium Compounds Prevent and Reverse Type-1 Diabetes in NOD Mice by Modulating α4β7 Integrin Activity, IL-1β, and T Regulatory Cells

The study shows that treatment of NOD mice with either of two tellurium-based small molecules, AS101 [ammonium trichloro(dioxoethylene-o,o')tellurate] or SAS [octa-O-bis-(R,R)-tartarate ditellurane] could preserve β cells function and mass. These beneficial effects were reflected in decreased i...

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Yossipof, Tom Eitan, Bazak, Ziva Roy, Kenigsbuch-Sredni, Dvora, Caspi, Rachel R., Kalechman, Yona, Sredni, Benjamin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549385/
https://ncbi.nlm.nih.gov/pubmed/31191514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00979
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