Metformin improves salivary gland inflammation and hypofunction in murine Sjögren’s syndrome

BACKGROUND: Activated T and B cells participate in the development and progression of Sjögren’s syndrome (SS). Metformin, a first-line anti-diabetic drug, exerts anti-inflammatory and immunomodulatory effects by activating AMPK. We investigated the therapeutic effect of metformin in non-obese diabet...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Kim, Ji-Won, Kim, Sung-Min, Park, Jin-Sil, Hwang, Sun-Hee, Choi, JeongWon, Jung, Kyung-Ah, Ryu, Jun-Geol, Lee, Seon-Yeong, Kwok, Seung-Ki, Cho, Mi-La, Park, Sung-Hwan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549273/
https://ncbi.nlm.nih.gov/pubmed/31164166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-019-1904-0
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