Tranilast enhances the effect of anticancer agents in osteosarcoma

Tranilast [N-(3′,4′-dimethoxycinnamoyl)-anthranilic acid], initially developed as an antiallergic drug, also exhibits a growth inhibitory effect on various types of cancer. Osteosarcoma is treated mainly with high-dose methotrexate, doxorubicin, cisplatin and ifosfamide; however, 20–30 % of patients...

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Bibliographic Details
Published in:Oncol Rep
Main Authors: Nakashima, Takayuki, Nagano, Satoshi, Setoguchi, Takao, Sasaki, Hiromi, Saitoh, Yoshinobu, Maeda, Shingo, Komiya, Setsuro, Taniguchi, Noboru
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2019
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549073/
https://ncbi.nlm.nih.gov/pubmed/31059083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2019.7150
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