A Genomic, Evolutionary, and Mechanistic Study of MCR‐5 Action Suggests Functional Unification across the MCR Family of Colistin Resistance

A growing number of mobile colistin resistance (MCR) proteins is threatening the renewed interest of colistin as a “last‐resort” defense against carbapenem‐resistant pathogens. Here, the comparative genomics of a large plasmid harboring mcr‐5 from Aeromonas hydrophila and the structural/functional p...

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Veröffentlicht in:Adv Sci (Weinh)
Hauptverfasser: Zhang, Huimin, Zong, Zhiyong, Lei, Sheng, Srinivas, Swaminath, Sun, Jian, Feng, Yu, Huang, Man, Feng, Youjun
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548960/
https://ncbi.nlm.nih.gov/pubmed/31179217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.201900034
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