O-GlcNAcylation enhances double strand break repair, promotes cancer cell proliferation and prevents therapy-induced senescence in irradiated tumors

The metabolic reprogramming associated with characteristic increases in glucose and glutamine metabolism common in advanced cancer is often ascribed to answering a higher demand for metabolic intermediates required for rapid tumor cell growth. Instead, recent discoveries have pointed to an alternati...

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Gepubliceerd in:Mol Cancer Res
Hoofdauteurs: Efimova, Elena V., Appelbe, Oliver K., Ricco, Natalia, Lee, Steve S.-Y., Liu, Yue, Wolfgeher, Donald J., Collins, Tamica N., Flor, Amy C., Ramamurthy, Aishwarya, Warrington, Sara, Bindokas, Vytautas P., Kron, Stephen J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548675/
https://ncbi.nlm.nih.gov/pubmed/30885991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-18-1025
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