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A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer
PTEN loss stimulates prostate tumor progression by sustaining AKT activation. Nowak et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902048) surprisingly show that the AKT-suppressing phosphatase PHLPP2 promotes disease progression in the context of dual PTEN and p53 loss by increasing MYC...
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| Publicado no: | J Cell Biol |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6548122/ https://ncbi.nlm.nih.gov/pubmed/31145683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201904119 |
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