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Molecular Basis for poly(A) RNP Architecture and Recognition by the Pan2-Pan3 Deadenylase
The stability of eukaryotic mRNAs is dependent on a ribonucleoprotein (RNP) complex of poly(A)-binding proteins (PABPC1/Pab1) organized on the poly(A) tail. This poly(A) RNP not only protects mRNAs from premature degradation but also stimulates the Pan2-Pan3 deadenylase complex to catalyze the first...
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| Gepubliceerd in: | Cell |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Cell Press
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6547884/ https://ncbi.nlm.nih.gov/pubmed/31104843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.04.013 |
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