DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions

Translation efficiency can be affected by mRNA stability and secondary structures, including G-quadruplex structures (G4s). The highly conserved DEAH-box helicase DHX36/RHAU resolves G4s on DNA and RNA in vitro, however a systems-wide analysis of DHX36 targets and function is lacking. We map globall...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Sauer, Markus, Juranek, Stefan A., Marks, James, De Magis, Alessio, Kazemier, Hinke G., Hilbig, Daniel, Benhalevy, Daniel, Wang, Xiantao, Hafner, Markus, Paeschke, Katrin
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547686/
https://ncbi.nlm.nih.gov/pubmed/31160600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10432-5
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