Senescent cells evade immune clearance via HLA-E-mediated NK and CD8(+) T cell inhibition

Senescent cells accumulate in human tissues during ageing and contribute to age-related pathologies. The mechanisms responsible for their accumulation are unclear. Here we show that senescent dermal fibroblasts express the non-classical MHC molecule HLA-E, which interacts with the inhibitory recepto...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Nat Commun
Main Authors: Pereira, Branca I., Devine, Oliver P., Vukmanovic-Stejic, Milica, Chambers, Emma S., Subramanian, Priya, Patel, Neil, Virasami, Alex, Sebire, Neil J., Kinsler, Veronica, Valdovinos, Alexis, LeSaux, Claude Jourdan, Passos, João F., Antoniou, Antony, Rustin, Malcom H. A., Campisi, Judith, Akbar, Arne N.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547655/
https://ncbi.nlm.nih.gov/pubmed/31160572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10335-5
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares