Inositol pyrophosphates mediated the apoptosis induced by hypoxic injury in bone marrow-derived mesenchymal stem cells by autophagy

OBJECTIVE: To investigate the potential effect of IP7 on the autophagy and apoptosis of bone marrow mesenchymal stem cells (BM-MSCs) caused by hypoxia. METHODS: BM-MSCs isolated from adult male C57BL/6 mice were exposed to normoxic condition and hypoxic stress for 6 h, 12 h, and 24 h, respectively....

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Bibliografiske detaljer
Udgivet i:Stem Cell Res Ther
Main Authors: Deng, Jingyu, Yang, Chao, Wang, Yong, Yang, Ming, Chen, Haixu, Ning, Hongjuan, Wang, Chengzhu, Liu, Yanjun, Zhang, Zheng, Hu, Taohong
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547565/
https://ncbi.nlm.nih.gov/pubmed/31159888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-019-1256-3
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