Modulation of HIV-1 Gag/Gag-Pol frameshifting by tRNA abundance

A hallmark of translation in human immunodeficiency virus type 1 (HIV-1) is a –1 programmed ribosome frameshifting event that produces the Gag-Pol fusion polyprotein. The constant Gag to Gag-Pol ratio is essential for the virion structure and infectivity. Here we show that the frameshifting efficien...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Korniy, Natalia, Goyal, Akanksha, Hoffmann, Markus, Samatova, Ekaterina, Peske, Frank, Pöhlmann, Stefan, Rodnina, Marina V
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Molecular Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547452/
https://ncbi.nlm.nih.gov/pubmed/30968122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz202
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