Mammalian CST averts replication failure by preventing G-quadruplex accumulation

Human CST (CTC1-STN1-TEN1) is an RPA-like complex that associates with G-rich single-strand DNA and helps resolve replication problems both at telomeres and genome-wide. We previously showed that CST binds and disrupts G-quadruplex (G4) DNA in vitro, suggesting that CST may prevent in vivo blocks to...

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Detaylı Bibliyografya
Yayımlandı:Nucleic Acids Res
Asıl Yazarlar: Zhang, Miaomiao, Wang, Bing, Li, Tingfang, Liu, Rui, Xiao, Yingnan, Geng, Xin, Li, Guang, Liu, Qiang, Price, Carolyn M, Liu, Yang, Wang, Feng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2019
Konular:
Molecular Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547417/
https://ncbi.nlm.nih.gov/pubmed/30976812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz264
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