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An Overview of Cancer Drugs Approved by the US Food and Drug Administration Based on the Surrogate End Point of Response Rate
IMPORTANCE: Approximately one-third of cancer drugs are approved based on response rate (RR)—the percentage of patients whose tumors shrink beyond an arbitrary threshold—typically assessed in a single-arm study. OBJECTIVE: To characterize RR end points used by the US Food and Drug Administration (FD...
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| Gepubliceerd in: | JAMA Intern Med |
|---|---|
| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Medical Association
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6547222/ https://ncbi.nlm.nih.gov/pubmed/31135822 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamainternmed.2019.0583 |
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