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Feed-forward regulation adaptively evolves via dynamics rather than topology when there is intrinsic noise
In transcriptional regulatory networks (TRNs), a canonical 3-node feed-forward loop (FFL) is hypothesized to evolve to filter out short spurious signals. We test this adaptive hypothesis against a novel null evolutionary model. Our mutational model captures the intrinsically high prevalence of weak...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6546794/ https://ncbi.nlm.nih.gov/pubmed/31160574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10388-6 |
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