Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter

Manganese superoxide dismutase (MnSOD) functions as a tumor suppressor; however, once tumorigenesis occurs, clinical data suggest MnSOD levels correlate with more aggressive human tumors, implying a potential dual function of MnSOD in the regulation of metabolism. Here we show, using in vitro transf...

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Pubblicato in:Nat Commun
Autori principali: Zhu, Yueming, Zou, Xianghui, Dean, Angela E., Brien, Joseph O’, Gao, Yucheng, Tran, Elizabeth L., Park, Seong-Hoon, Liu, Guoxiang, Kieffer, Matthew B., Jiang, Haiyan, Stauffer, Melissa E., Hart, Robert, Quan, Songhua, Satchell, Karla J. F., Horikoshi, Nobuo, Bonini, Marcelo, Gius, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546705/
https://ncbi.nlm.nih.gov/pubmed/31160585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10352-4
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