Posttransplantation cyclophosphamide prevents graft-versus-host disease by inducing alloreactive T cell dysfunction and suppression

Posttransplantation cyclophosphamide (PTCy) recently has had a marked impact on human allogeneic hematopoietic cell transplantation (HCT). Yet our understanding of how PTCy prevents graft-versus-host disease (GVHD) largely has been extrapolated from MHC-matched murine skin-allografting models that w...

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Udgivet i:J Clin Invest
Main Authors: Wachsmuth, Lucas P., Patterson, Michael T., Eckhaus, Michael A., Venzon, David J., Gress, Ronald E., Kanakry, Christopher G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546453/
https://ncbi.nlm.nih.gov/pubmed/30913039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI124218
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