Heritability in genetic heart disease: the role of genetic background

BACKGROUND: Mutations in genes encoding ion channels or sarcomeric proteins are an important cause of hereditary cardiac disease. However, the severity of the resultant disease varies considerably even among those with an identical mutation. Such clinical variation is often thought to be explained l...

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Veröffentlicht in:Open Heart
Hauptverfasser: Jansweijer, Joeri A, van Spaendonck-Zwarts, Karin Y, Tanck, Michael W T, van Tintelen, J Peter, Christiaans, Imke, van der Smagt, Jasper J, Vermeer, Alexa M C, Bos, J Martijn, Moss, Arthur J, Swan, Heikki, Priori, Sylvia G, Rydberg, Annika, Tfelt-Hansen, Jacob, Ackerman, Michael J, Olivotto, Iacopo, Charron, Philippe, Gimeno, Juan R, van den Berg, Maarten P, Wilde, Arthur AM, Pinto, Yigal M
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2019
Schlagworte:
Basic and Translational Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546190/
https://ncbi.nlm.nih.gov/pubmed/31245010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/openhrt-2018-000929
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