MRI-Guided Focused Ultrasound for Targeted Delivery of rAAV to the Brain

Recombinant adeno-associated viral (rAAV) vectors are a promising tool for therapeutic gene delivery to the brain. However, the delivery of rAAVs across the blood-brain barrier (BBB) and entry into the brain remains a major challenge for rAAV-based gene therapy. To circumvent this limitation, transc...

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Udgivet i:Methods Mol Biol
Main Authors: Noroozian, Zeinab, Xhima, Kristiana, Huang, Yuexi, Kaspar, Brian K., Kügler, Sebastian, Hynynen, Kullervo, Aubert, Isabelle
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546162/
https://ncbi.nlm.nih.gov/pubmed/30783974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-9139-6_10
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