Hepatic transcriptomic signatures of statin treatment are associated with impaired glucose homeostasis in severely obese patients

BACKGROUND: Clinical data identified an association between the use of HMG-CoA reductase inhibitors (statins) and incident diabetes in patients with underlying diabetes risk factors such as obesity, hypertension and dyslipidemia. The molecular mechanisms however are unknown. METHODS: An observationa...

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Vydáno v:BMC Med Genomics
Hlavní autoři: Margerie, Daniel, Lefebvre, Philippe, Raverdy, Violeta, Schwahn, Uwe, Ruetten, Hartmut, Larsen, Philip, Duhamel, Alain, Labreuche, Julien, Thuillier, Dorothée, Derudas, Bruno, Gheeraert, Céline, Dehondt, Hélène, Dhalluin, Quentin, Alexandre, Jérémy, Caiazzo, Robert, Nesslany, Pamela, Verkindt, Helene, Pattou, François, Staels, Bart
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6545676/
https://ncbi.nlm.nih.gov/pubmed/31159817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-019-0536-1
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