Down-Regulation of MYCN Protein by CX-5461 Leads to Neuroblastoma Tumor Growth Suppression

PURPOSE: MYCN oncogene amplification is an independent predictor of poor prognosis in neuroblastoma. CX-5461 is a small molecular inhibitor that prevents initiation of ribosomal RNA (rRNA) synthesis by RNA Pol I, down-regulating MYCN/MYC proteins. We hypothesize that neuroblastoma tumor growth can b...

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Publicado no:J Pediatr Surg
Main Authors: Taylor, Jordan S., Zeki, Jasmine, Ornell, Kimberly, Coburn, Jeannine, Shimada, Hiroyuki, Ikegaki, Naohiko, Chiu, Bill
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6545249/
https://ncbi.nlm.nih.gov/pubmed/30879743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpedsurg.2019.02.028
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