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Do cytomegalovirus-specific memory T cells interfere with new immune responses in lymphoid tissues?

In both mice and humans, the CD8 T cell compartment is expanded with age in the presence of a cytomegalovirus (CMV) infection due to an absolute increase in the CD8+ T cell effector memory (T(EM)) cells. It has been hypothesized that in CMV+ subjects, such accumulated T(EM) cells could interfere wit...

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Опубликовано в: :GeroScience
Главные авторы: Jergović, Mladen, Uhrlaub, Jennifer L., Contreras, Nico A., Nikolich-Žugich, Janko
Формат: Artigo
Язык:Inglês
Опубликовано: Springer International Publishing 2019
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544713/
https://ncbi.nlm.nih.gov/pubmed/31069636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-019-00068-0
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