Dual Chemical Probes Enable Quantitative System-Wide Analysis of Protein Prenylation and Prenylation Dynamics

Post-translational farnesylation or geranylgeranylation at a C-terminal cysteine residue regulates localization and function of over 100 proteins, including the Ras isoforms, and is a therapeutic target in diseases including cancer and infection. Here we report global and selective profiling of pren...

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Detalhes bibliográficos
Publicado no:Nat Chem
Main Authors: Storck, Elisabeth M., Morales-Sanfrutos, Julia, Serwa, Remigiusz A., Panyain, Nattawadee, Lanyon-Hogg, Thomas, Tolmachova, Tanya, Ventimiglia, Leandro N., Martin-Serrano, Juan, Seabra, Miguel C., Wojciak-Stothard, Beata, Tate, Edward W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544531/
https://ncbi.nlm.nih.gov/pubmed/30936521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-019-0237-6
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