A computationally identified compound antagonizes excess FGF-23 signaling in renal tubules and a mouse model of hypophosphatemia

Fibroblast growth factor-23 (FGF-23) interacts with a binary receptor complex composed of α-Klotho (α-KL) and FGF receptors (FGFRs) to regulate phosphate and vitamin D metabolism in the kidney. Excess FGF-23 production, which causes hypophosphatemia, is genetically inherited or occurs with chronic k...

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Vydáno v:Sci Signal
Hlavní autoři: Xiao, Zhousheng, Riccardi, Demian, Velazquez, Hector A., Chin, Ai L., Yates, Charles R., Carrick, Jesse D., Smith, Jeremy C., Baudry, Jerome, Quarles, L. Darryl
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544179/
https://ncbi.nlm.nih.gov/pubmed/27879395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaf5034
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