PD-1/PD-L1 immune checkpoint and p53 loss facilitate tumor progression in activated B-cell diffuse large B-cell lymphomas

Refractory or relapsed diffuse large B-cell lymphoma (DLBCL) often associates with the activated B-cell-like (ABC) subtype and genetic alterations that drive constitutive NF-κB activation and impair B-cell terminal differentiation. Here, we show that DNA damage response by p53 is a central mechanism...

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Publicat a:Blood
Autors principals: Pascual, Marién, Mena-Varas, María, Robles, Eloy Francisco, Garcia-Barchino, Maria-Jose, Panizo, Carlos, Hervas-Stubbs, Sandra, Alignani, Diego, Sagardoy, Ainara, Martinez-Ferrandis, Jose Ignacio, Bunting, Karen L., Meier, Stephen, Sagaert, Xavier, Bagnara, Davide, Guruceaga, Elizabeth, Blanco, Oscar, Celay, Jon, Martínez-Baztan, Alvaro, Casares, Noelia, Lasarte, Juan José, MacCarthy, Thomas, Melnick, Ari, Martinez-Climent, Jose Angel, Roa, Sergio
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2019
Matèries:
Immunobiology and Immunotherapy
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6543517/
https://ncbi.nlm.nih.gov/pubmed/30975638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2018889931
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