PNA Length Restriction of Antibacterial Activity of Peptide-PNA Conjugates in Escherichia coli Through Effects of the Inner Membrane

Peptide Nucleic Acid (PNA)-peptide conjugates targeting essential bacterial genes are showing promise as antisense antimicrobials in drug discovery. Optimization has focused on selection of target genes and exact localization around the ribosome binding site, but surprisingly a length optimum around...

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Vydáno v:Front Microbiol
Hlavní autoři: Goltermann, Lise, Yavari, Niloofar, Zhang, Meiqin, Ghosal, Anubrata, Nielsen, Peter E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Microbiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542938/
https://ncbi.nlm.nih.gov/pubmed/31178830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.01032
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