CTLA-4 Protects against Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice

Vascular inflammation via T-cell-mediated immune responses has been shown to be critically involved in the pathogenesis of abdominal aortic aneurysm (AAA). T-cell coinhibitory molecule cytotoxic T-lymphocyte–associated antigen-4 (CTLA-4) is known to act as a potent negative regulator of immune respo...

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Vydáno v:Sci Rep
Hlavní autoři: Amin, Hilman Zulkifli, Sasaki, Naoto, Yamashita, Tomoya, Mizoguchi, Taiji, Hayashi, Tomohiro, Emoto, Takuo, Matsumoto, Takuya, Yoshida, Naofumi, Tabata, Tokiko, Horibe, Sayo, Kawauchi, Shoji, Rikitake, Yoshiyuki, Hirata, Ken-ichi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542846/
https://ncbi.nlm.nih.gov/pubmed/31147569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44523-6
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