Multiplexed Targeting of Barrett’s Neoplasia with a Heterobivalent Ligand: Imaging Study on Mouse Xenograft In Vivo and Human Specimens Ex Vivo

Esophageal adenocarcinoma (EAC) is a molecularly heterogeneous disease that is rising rapidly in incidence and has poor prognosis. We developed a heterobivalent peptide to target detection of early Barrett’s neoplasia by combining monomer heptapeptides specific for either EGFR or ErbB2 in a heterodi...

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Gepubliceerd in:J Med Chem
Hoofdauteurs: Chen, Jing, Zhou, Juan, Gao, Zhenghong, Li, Xue, Wang, Fa, Duan, Xiyu, Li, Gaoming, Joshi, Bishnu P., Kuick, Rork, Appelman, Henry D., Wang, Thomas D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542277/
https://ncbi.nlm.nih.gov/pubmed/29870260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00405
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