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Noncovalent, Electrostatic Interactions Induce Positively Cooperative Binding of Small Molecules to Alzheimer’s and Parkinson’s Disease-Related Amyloids
Amyloids are self-assembled protein aggregates that represent a major hallmark of many neurologic and systemic diseases. Among the common features of amyloids is the presence of a high density of multiple binding sites for small molecule ligands, making them an attractive target for design of multim...
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| Publicado no: | ACS Chem Neurosci |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6541930/ https://ncbi.nlm.nih.gov/pubmed/30044911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00280 |
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