Synthesis, comparative docking, and pharmacological activity of naproxen amino acid derivatives as possible anti-inflammatory and analgesic agents

Background and aim: Naproxen is a member of the Nonsteroidal anti-inflammatory drugs (NSAIDs). This work aimed to synthesize a safe NSAID agent based on a peptide derivative. Methods: The structure of compounds 5–20 was established on the basis of spectral data. Frontier molecular orbitals and chemi...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Elhenawy, Ahmed A, Al-Harbi, LM, Moustafa, Gaber O, El-Gazzar, MA, Abdel-Rahman, Rehab F, Salim, Abd Elhamid
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6540076/
https://ncbi.nlm.nih.gov/pubmed/31213767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S196276
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