Binding Heterogeneity of Plasmodium falciparum to Engineered 3D Brain Microvessels Is Mediated by EPCR and ICAM-1

Cerebral malaria is a severe neurological complication associated with sequestration of Plasmodium falciparum-infected erythrocytes (IE) in the brain microvasculature, but the specific binding interactions remain under debate. Here, we have generated an engineered three-dimensional (3D) human brain...

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Pubblicato in:mBio
Autori principali: Bernabeu, Maria, Gunnarsson, Celina, Vishnyakova, Maria, Howard, Caitlin C., Nagao, Ryan J., Avril, Marion, Taylor, Terrie E., Seydel, Karl B., Zheng, Ying, Smith, Joseph D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538777/
https://ncbi.nlm.nih.gov/pubmed/31138740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00420-19
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