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Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

Recent history is punctuated by the emergence of highly pathogenic coronaviruses such as SARS- and MERS-CoV into human circulation. Upon infecting host cells, coronaviruses assemble a multi-subunit RNA-synthesis complex of viral non-structural proteins (nsp) responsible for the replication and trans...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kirchdoerfer, Robert N., Ward, Andrew B.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538669/
https://ncbi.nlm.nih.gov/pubmed/31138817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10280-3
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