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Absence of recipient C3aR1 signaling limits expansion and differentiation of alloreactive CD8(+) T cell immunity and prolongs murine cardiac allograft survival

Activation, differentiation and expansion of alloreactive CD8(+) T cells, the dominant effectors that mediate murine heart allograft rejection, requires allorecognition, costimulation, and cytokine-initiated signals. While previous work showed that alloreactive CD4(+) T cell immunity entails immune...

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Publicat a:Am J Transplant
Autors principals: Mathern, Douglas R., Horwitz, Julian, Heeger, Peter S.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538425/
https://ncbi.nlm.nih.gov/pubmed/30565852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.15222
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