Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation

Cancer evolves through a multistep process that occurs by the temporal accumulation of genetic mutations. Tumor-derived exosomes are emerging contributors to tumorigenesis. To understand how exosomes might contribute to cell transformation, we utilized the classic two-step NIH/3T3 cell transformatio...

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Библиографические подробности
Опубликовано в: :eLife
Главные авторы: Stefanius, Karoliina, Servage, Kelly, de Souza Santos, Marcela, Gray, Hillery Fields, Toombs, Jason E, Chimalapati, Suneeta, Kim, Min S, Malladi, Venkat S, Brekken, Rolf, Orth, Kim
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2019
Предметы:
Cancer Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538373/
https://ncbi.nlm.nih.gov/pubmed/31134894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.40226
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