Structure-guided exploration of SDS22 interactions with protein phosphatase PP1 and the splicing factor BCLAF1

SDS22 is an ancient regulator of protein phosphatase-1 (PP1). Our crystal structure of SDS22 shows that its twelve leucine-rich repeats adopt a banana-shaped fold that is shielded from solvent by capping domains at its extremities. Subsequent modeling and biochemical studies revealed that the concav...

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Publicado en:Structure
Main Authors: Heroes, Ewald, Van der Hoeven, Gerd, Choy, Meng S., del Pino Garcia, Javier, Ferreira, Mónica, Nys, Mieke, Derua, Rita, Beullens, Monique, Ulens, Chris, Peti, Wolfgang, Van Meervelt, Luc, Page, Rebecca, Bollen, Mathieu
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538287/
https://ncbi.nlm.nih.gov/pubmed/30661852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2018.12.002
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