Iron-related nigral degeneration influences functional topology mediated by striatal dysfunction in Parkinson’s disease

In Parkinson’s disease (PD), iron accumulation in the substantia nigra (SN) exacerbates oxidative stress and α-synuclein aggregation, leading to neuronal death. However, the influence of iron-related nigral degeneration on the subcortical function and global network configuration in PD remains unkno...

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Pubblicato in:Neurobiol Aging
Autori principali: Guan, Xiaojun, Zhang, Yuyao, Wei, Hongjiang, Guo, Tao, Zeng, Qiaoling, Zhou, Cheng, Wang, Jiaqiu, Gao, Ting, Xuan, Min, Gu, Quanquan, Xu, Xiaojun, Huang, Peiyu, Pu, Jiali, Zhang, Baorong, Liu, Chunlei, Zhang, Minming
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538269/
https://ncbi.nlm.nih.gov/pubmed/30554085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2018.11.013
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