Programmable design of orthogonal protein heterodimers

Heterodimeric interaction specificity between two DNA strands, and between protein and DNA, is often achieved by varying side chains or bases coming off the protein or DNA backbone -- for example, the bases participating in Watson-Crick base pairing in the double helix, or the side chains of protein...

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Publicado en:Nature
Main Authors: Chen, Zibo, Boyken, Scott E., Jia, Mengxuan, Busch, Florian, Flores-Solis, David, Bick, Matthew J., Lu, Peilong, VanAernum, Zachary L., Sahasrabuddhe, Aniruddha, Langan, Robert A., Bermeo, Sherry, Brunette, TJ, Mulligan, Vikram K., Carter, Lauren P., DiMaio, Frank, Sgourakis, Nikolaos G., Wysocki, Vicki H., Baker, David
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6537907/
https://ncbi.nlm.nih.gov/pubmed/30568301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0802-y
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