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HIV-induced matrix metalloproteinase-9 activation through mitogen-activated protein kinase signalling promotes HSV-1 cell-to-cell spread in oral epithelial cells

We have shown that cell-free HIV-1 and viral proteins tat and gp120 activate mitogen-activated protein kinases (MAPKs) in tonsil epithelial cells, disrupting their tight and adherens junctions. This causes liberation of the HSV-1 receptor nectin-1 from assembled adherens junctions, leading to promot...

詳細記述

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書誌詳細
出版年:J Gen Virol
主要な著者: Sufiawati, Irna, Tugizov, Sharof M.
フォーマット: Artigo
言語:Inglês
出版事項: Microbiology Society 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6537617/
https://ncbi.nlm.nih.gov/pubmed/29775175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/jgv.0.001075
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